Journal
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Volume 58, Issue 3, Pages 564-569Publisher
WILEY
DOI: 10.1111/j.1532-5415.2010.02725.x
Keywords
longevity; insulin resistance; metabolic syndrome
Categories
Funding
- Innovation Oriented research Program on Genomics [IGE01014, IGE5007]
- Centre for Medical Systems Biology
- Netherlands Genomics Initiative/Netherlands Organization for scientific research [05040202, 050-060-810]
- European Union [FP6 036894]
Ask authors/readers for more resources
OBJECTIVES To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity. DESIGN Case-control study. SETTING A university hospital in Leiden, the Netherlands. PARTICIPANTS One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus. MEASUREMENTS Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program. Glucose tolerance was assessed according to a 2-hour oral glucose tolerance test. RESULTS The offspring of nonagenarians siblings had a lower prevalence of metabolic syndrome (P=.03), similar body composition, lower mean fasting blood glucose levels (4.99 vs 5.16 mmol/L; P=.01), lower mean fasting insulin levels (5.81 vs 6.75 mU/L; P=.04), a higher mean homeostasis model assessment of insulin sensitivity (0.78 vs 0.65; P=.02), and a more-favorable glucose tolerance (mean area under the receiver operating characteristic curve for glucose (13.2 vs 14.3; P=.007) than their partners. No significant differences were observed between the offspring and their partners in beta-cell function (insulogenic index 13.6 vs 12.5; P=.38). CONCLUSION Despite similar body composition, the offspring of nonagenarian siblings showed a lower prevalence of metabolic syndrome and better glucose tolerance than their partners, centralizing the role of favorable glucose metabolism in familial longevity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available