Journal
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
Volume 30, Issue 3, Pages 210-215Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/07315724.2011.10719962
Keywords
homocysteine; malondialdehyde; type 2 diabetes mellitus; total antioxidant capacity
Categories
Funding
- Tabriz University of Medical Sciences
- Nutrition Research Center
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Objective: Metformin is widely used in patients with type 2 diabetes, but it may decrease vitamin B12 and folate levels and increase levels of homocysteine (Hcy). Hyperhomocysteinemia (HHC) and hyperglycemia induce oxidative stress in type 2 diabetes. Thus, this study was performed to determine the effects of folate supplementation on the concentration of homocysteine, total antioxidant capacity (TAC), and malondialdehyde (MDA). Methods: This was a double-blind randomized controlled clinical trial. Sixty-eight men with type 2 diabetes participated in the study with written consent. Patients were divided randomly into 2 groups: folic acid 5 mg/d and placebo. All patients received the tablets for 8 weeks. Anthropometric and nutrient intake data were obtained from each patient. Baseline and eighth-week homocysteine, total antioxidant capacity, malondialdehyde, folate, and B12 levels were measured. Results: After folate supplementation in the folic acid group, homocysteine was significantly decreased (15.1 +/- 3.2 to 12.1 +/- 3.1 mu mol/L, p < 0.001) and folate and B12 levels were significantly increased (p < 0.001). A significant increase in total antioxidant capacity (0.96 +/- 0.2 to 1.14 +/- 0.3 mmol Fe2+/L, p < 0.001) and a significant decrease in malondialdehyde (2.6 +/- 0.7 to 1.7 +/- 0.2 mu mol/L, p < 0.001) were observed in the folic acid group, whereas no significant changes occurred in the placebo group (p > 0.05). Conclusion: Pharmacological doses of folate supplementation lowered plasma homocysteine and serum malondialdehyde levels and improved serum total antioxidant capacity and folate and B12 levels in patients with type 2 diabetes.
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