Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 63, Issue 24, Pages 2659-2673Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2014.02.545
Keywords
bare-metal stents; drug-coated balloons; drug-eluting stents; in-stent restenosis; intravascular ultrasound; neoatherosclerosis; optical coherence tomography
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Funding
- B. Braun
- Biotronik
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Management of patients with in-stent restenosis (ISR) remains an important clinical problem. Although drug-eluting stents (DES) have drastically reduced the incidence of ISR, treatment of DES-ISR is particularly challenging. ISR mainly results from aggressive neointimal proliferation, but recent data also suggest that neoatherosclerosis may play an important pathophysiological role. Intracoronary imaging provides unique insights to unravel the underlying substrate of ISR and may be used to guide repeated interventions. In this paper, we systematically reviewed clinical trial data with currently available therapeutic modalities, including DES and drug-coated balloons, in patients presenting with ISR within bare-metal stents or DES. (c) 2014 by the American College of Cardiology Foundation
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