Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 58, Issue 23, Pages 2357-2362Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2011.08.034
Keywords
chemokine; inflammation; myocardial infarction; remodeling
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Despite considerable progress over the last decades, acute myocardial infarction continues to remain the major cause of morbidity and mortality worldwide. The present therapies include only cause-dependent interventions, which are not able to reduce myocardial necrosis and optimize cardiac repair following infarction. This review highlights the cellular and molecular processes after myocardial injury and focuses on chemokines, the main modulators of the inflammatory and reparatory events, as the most valuable drug targets. (J Am Coll Cardiol 2011; 58: 2357-62) (C) 2011 by the American College of Cardiology Foundation
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