Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 55, Issue 4, Pages 271-282Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2009.08.059
Keywords
mitral regurgitation; heart failure; cardiac surgery
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The appropriateness and timing of mitral valve surgery in patients with advanced heart failure and severe mitral regurgitation remains controversial. Recent surgical results provide evidence for beneficial effects on left ventricular remodeling and functional capacity. Given the absence of randomized trials comparing the outcomes of mitral valve surgery to medical therapy, however, clinical decision making regarding surgery for these fragile patients poses a dilemma to thoughtful clinicians. This paper reviews the pathophysiology of mitral regurgitation in heart failure and proposes an integrated approach to management. (J Am Coll Cardiol 2010; 55: 271-82) (C) 2010 by the American College of Cardiology Foundation
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