Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 38, Pages 11893-11897Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b06313
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Funding
- NSFC [21572109, 21332004, 21702109, 21740002]
- Natural Science Foundation of Tianjin City [15JCYBJC53300, 18JCYBJC21400]
- Slovenian Research Agency (ARRS) [P1-0242, J1-6733]
- National Thousand Young Talents Program of China and Tianjin
- Fundamental Research Funds for the Central Universities
- CERIC-ERIC Consortium
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RNA cleavage via internal transesterification is a fundamental reaction involved in RNA processing and metabolism, and the regulation thereof. Herein, the influence of ribose conformation on this reaction was investigated with conformationally constrained ribonucleotides. RNA cleavage rates were found to decrease in the order South-constrained ribonucleotide > native ribonucleotide >> North-constrained counterpart, indicating that the ribose conformation plays an important role in modulating RNA cleavage via internal transesterification.
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