Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 34, Pages 10658-10662Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b05668
Keywords
-
Categories
Funding
- NIGMS MIRA [R35 GM122525]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM122525] Funding Source: NIH RePORTER
Ask authors/readers for more resources
We report the development of Pd(II)/cis-aryl sulfoxide-oxazoline (cis-ArSOX) catalysts for asymmetric C-H alkylation of terminal olefins with a variety of synthetically versatile nucleophiles. The modular, tunable, and oxidatively stable ArSOX scaffold is key to the unprecedented broad scope and high enantioselectivity (37 examples, avg. > 90% ee). Pd(II)/cis-ArSOX is unique in its ability to effect high reactivity and catalyst-controlled diastereoselectivity on the alkylation of aliphatic olefins. We anticipate that this new chiral ligand class will find use in other transition metal catalyzed processes that operate under oxidative conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available