Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 50, Pages 17645-17651Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja510653n
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Funding
- Chinese NSF [21172140, 21372151]
- Program for Professor of Special Appointment at Shanghai Institutions of Higher Learning (Dongfang Scholar) Shanghai Education Committee
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This work highlights Ni-catalyzed reductive coupling of alkyl acids with alkyl halides, particularly sterically hindered unactivated tertiary alkyl bromides for the production of all carbon quaternary ketones. The reductive strategy is applicable to alpha-selective synthesis of saturated, fully oxygenated C-acyl glycosides through easy manipulations of the readily available sugar bromides and alkyl acids, avoiding otherwise difficult multistep conversions. Initial mechanistic studies suggest that a radical chain mechanism (cycle B, Scheme 1) may be plausible, wherein MgCl2 promotes the reduction of Ni-II complexes.
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