Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 24, Pages 8544-8547Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja5039616
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Funding
- MEXT, Japan [25810061]
- Grants-in-Aid for Scientific Research [25810061, 25288047, 26105735] Funding Source: KAKEN
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A palladium-catalyzed stereospecific and regioselective cross-coupling of enantiopure 2-arylaziridines with arylboronic acids under mild conditions to construct a tertiary stereogenic center has been developed. N-heterocyclic carbene (NHC) ligands efficiently promote the coupling, suppressing beta-hydride elimination. The enantiospecific cross-coupling allowed us for preparation of a series of biologically important 2-arylphenethylamine derivatives in an enantiopure form.
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