Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 4, Pages 1256-1259Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja4114903
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Funding
- National Key Scientific Program of China [2011CB911000]
- NSFC [21221003, 21327009]
- China National Instrumentation Program [2011YQ03012412]
- National Institutes of Health [GM079359, CA133086]
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Cell types, both healthy and diseased, can be classified by inventories of their cell-surface markers. Programmable analysis of multiple markers would enable clinicians to develop a comprehensive disease profile, leading to more accurate diagnosis and intervention. As a first step to accomplish this, we have designed a DNA-based device, called Nano-Claw. Combining the special structure-switching properties of DNA aptamers with toehold-mediated strand displacement reactions, this claw is capable of performing autonomous logic-based analysis of multiple cancer cell-surface markers and, in response, producing a diagnostic signal and/or targeted photodynamic therapy. We anticipate that this design can be widely applied in facilitating basic biomedical research, accurate disease diagnosis, and effective therapy.
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