Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 21, Pages 7567-7570Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja5029556
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Funding
- MEXT [22105003]
- Grants-in-Aid for Scientific Research [26810058, 22105003] Funding Source: KAKEN
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Arylboration of vinylarenes and methyl crotonate with aryl halides and bis(pinacolato)diboron by cooperative Pd/Cu catalysis has been developed, giving 2-boryl-1,1-diarylethanes and an alpha-aryl-beta-boryl ester in a regioselective manner. The reaction is compatible with a variety of functionalities and amenable to be scaled-up to a gram scale with no detriment to the yield. A short synthesis of the biologically active compound CDP840 was performed using the present reaction as a key step.
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