Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 17, Pages 6401-6405Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja501635u
Keywords
-
Categories
Funding
- Center of Molecular Analysis and Design (CMAD)
- China Scholarship Council
- Ministry of Education of China [201206010110]
- NIH [R01 NS045684]
Ask authors/readers for more resources
Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small molecules having different sample preparation. physicochemical properties without the need for extensive
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available