Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 8, Pages 3006-3009Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja412962w
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- ETH Zurich
- Swiss National Science Foundation
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The direct Ir-catalyzed cross-coupling between branched, racemic allylic alcohols and simple olefins is described. This transformation is catalyzed by an Ir-(P,olefin) complex and proceeds with high site selectivity and excellent enantioselectivity. The method allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthesis of the gamma-secretase modulator JNJ-40418677.
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