Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 24, Pages 8693-8701Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja5026326
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Funding
- RecerCaixa foundation [2010ACUP00378]
- Marato de TV3 foundation [111531]
- Human Frontier Science Program [CDA022/2006]
- European Research Council [ERC-2007-StG-210355, ERC-2012-PoC-335011]
- European Commission [FP7-ICT-2009-270483]
- Catalan government [2009-SGR-277, 2012-FI_B 01122]
- Universitat Autonoma de Barcelona
- Spanish government [CTQ2008-06160, CTQ2012-30853, CTQ2010-15380]
- Spanish government (FPU) [AP2008-03313]
- NIDA [R21DA034195]
- NIHM [R01MH101218]
- Deutsche Forschungsgemeinschaft [HI 1728/1-1]
- U.S. Army Research Laboratory
- U.S. Army Research Office [W911NF-12-1-0594 (MURI)]
- ICREA Funding Source: Custom
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Synthetic photochromic compounds can be designed to control a variety of proteins and their biochemical functions in living cells, but the high spatiotemporal precision and tissue penetration of two-photon stimulation have never been investigated in these molecules. Here we demonstrate two-photon excitation of azobenzene-based protein switches and versatile strategies to enhance their photochemical responses. This enables new applications to control the activation of neurons and astrocytes with cellular and subcellular resolution.
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