Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 34, Pages 11902-11905Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja505962w
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Funding
- Robert A. Welch Foundation [F-0038]
- NIFI-NIGMS [RO1-GM069445]
- Dorothy B. Banks graduate fellowship program
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The cationic ruthenium catalyst generated upon the acid-base reaction of H2Ru(CO)(PPh3)(3) and 2,4,6-(2-Pr)(3)PhSO3H promotes the redox-triggered C-C coupling of 2-alkynes and primary alcohols to form (Z)-homoallylic alcohols with good to complete control of olefin geometry. Deuterium labeling studies, which reveal roughly equal isotopic compositions at the allylic and distal vinylic positions, along with other data, corroborate a catalytic mechanism involving ruthenium(0)-mediated allene-aldehyde oxidative coupling to form a transient oxaruthenacycle, an event that ultimately defines (Z)-olefin stereochemistry.
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