4.8 Article

Total Synthesis of Nucleoside Antibiotic A201A

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 11, Pages 4157-4160

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja501460j

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Funding

  1. MOST [2012CB822102]
  2. NSFC [21302210, 20921091]

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A201A, a unique nucleoside antibiotic with potent antibacterial activities, has been synthesized for the first time in a total of 47 steps in a highly modular and linear manner, highlighting the elaboration/incorporation of an unprecedented hexofuranoside unit bearing an exocyclic enol ether moiety.

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