Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 39, Pages 13614-13617Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja508523g
Keywords
-
Categories
Funding
- National Institutes of Health [GM-099920, GM-43214]
- NSERC
- Vertex Pharmaceuticals, Inc.
- NIH [GM-067041]
Ask authors/readers for more resources
We report the development of a catalytic method for the enantioselective addition of indoles to pyrone-derived electrophiles. Arylpyrrolidino-derived thioureas catalyze the addition with high stereoselectivity in the presence of catalytic quantities of an achiral Bronsted acid. The indole-pyrone adducts feature a quaternary stereocenter and represent an unusual class of indolines bearing structural resemblance to the hybrid natural product pleiocarpamine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
