Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 24, Pages 8524-8527Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja503270n
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Funding
- MIUR, FIRB project FLUORIMAG-ING [RBAP1183B5]
- Regione Lombardia (Fondo per lo Sviluppo e la Coesione - FAS)
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F-19-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo, Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo F-19-MRI applications. The molecule, which bears 36 equivalent F-19 atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.
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