Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 12, Pages 4697-4705Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja500315x
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Funding
- National Science Foundation [CHE-1265770]
- NIH [IS10RR13886-01, T32 GM008334]
- Paul E. Gray Endowed Fund for UROP
- Swiss National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1265770] Funding Source: National Science Foundation
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The first near-infrared fluorescent turn-on sensor for the detection of nitroxyl (F(NO), the one-electron reduced form of nitric oxide (NO), is reported. The new copper-based probe, CuDHX1, contains a dihydroxanthene (DHX) fluorophore and a cyclam derivative as a Cu(II) binding site. Upon reaction with HNO, CuDHX1 displays a five-fold fluorescence turn-on in cuvettes and is selective for HNO over thiols and reactive nitrogen and oxygen species. CuDHX1 can detect exogenously applied HNO in live mammalian cells and in conjunction with the zinc-specific, green-fluorescent sensor ZP1 can perform multicolor/multianalyte microscopic imaging. These studies reveal that HNO treatment elicits an increase in the concentration of intracellular mobile zinc.
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