Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 41, Pages 14397-14400Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja508542n
Keywords
-
Categories
Funding
- Australian Research Council [DP120101315]
- Future Fellowship programs [FT110100319]
Ask authors/readers for more resources
The enantioselective vinylogous Michael/aldol cascade is an underdeveloped approach to cyclohexenes. Herein we describe a highly enantioselective (most >= 98:2 er) and diastereoselective (all >= 15:1 dr) N-heterocyclic carbene catalyzed cycloisomerization of acyclic dienyl esters to cyclohexyl beta-lactones. Derivatizations avail cyclohexenes bearing four contiguous stereogenic centers, while mechanistic studies support olefin isomerization prior to cyclization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available