4.8 Article

Intramolecular Dearomatizing [3+2] Annulation of α-Imino Carbenoids with Aryl Rings Furnishing 3,4-Fused Indole Skeletons

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 136, Issue 6, Pages 2272-2275

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja412663a

Keywords

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Funding

  1. MEXT [22105005, 24106718, 23685019, 23350041]
  2. JST (ACT-C)
  3. Grants-in-Aid for Scientific Research [24106718, 23685019, 14J05174, 22105005, 23350041] Funding Source: KAKEN

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The rhodium-catalyzed dearomatizing [3 + 2] annulation reaction of 4-(3-arylpropyl)-1,2,3-triazoles is described. It provides a straightforward synthetic pathway from simple 5-aryl-1-alkynes leading to tricyclic 3,4-fused dihydroindoles via the corresponding 1,2,3-triazoles.

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