Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 6, Pages 2124-2127Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja312277g
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Funding
- Pennsylvania State University
- NSF [CHE-1055795]
- ACS-PRF [51705-DNI1]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1055795] Funding Source: National Science Foundation
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We report an efficient method for the alkylation of gamma-C(sp(3))-H bonds of picolinamide-protected aliphatic amine substrates with primary alkyl iodides via palladium catalysis. Ag2CO3 and dibenzyl phosphate, (BnO)(2)PO2H, are critical promoters of this reaction. These reactions provide a convenient and straightforward method for the preparation of high-value N-containing products from readily available amine and alkyl iodide precursors.
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