Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 46, Pages 17494-17500Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja410815u
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Funding
- NIH/NIGMS [R01-GM079554]
- Welch Foundation [I-1596]
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We report herein an operationally simple method for the direct conversion of benzylic C H groups to C F. We show that visible light can activate diarylketones to abstract a benzylic hydrogen atom selectively. Adding a fluorine radical donor yields the benzylic fluoride and regenerates the catalyst. The selective formation of mono- and difluorination products can be achieved by catalyst control. 9-Fluorenone catalyzes benzylic C-H monofluorination, while xanthone catalyzes benzylic C H difluorination. The scope and efficiency of this new C H fluorination method are significantly better than those of the existing methods. This is also the first report of selective C H gem-difluorination.
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