Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 24, Pages 8770-8773Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja400636d
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Funding
- National Institutes of Health [1R21 HL097314, 1R01 HL109192, 1R25CA154015A]
- Biomedical Research Center, a joint venture of Carle Foundation Hospital
- University of Illinois at Urbana-Champaign
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Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.
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