Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 4, Pages 1232-1235Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja311202e
Keywords
-
Categories
Funding
- National University of Singapore [143-000-509-112]
- NUS Research Scholarship
- President's Graduate Fellowship
Ask authors/readers for more resources
A catalytic asymmetric bromocyclization of trisubstituted olefinic amides that uses a C-2-symmetric mannitol-derived cyclic selenium catalyst and a stoichiometric amount of N-bromophthalimide is reported. The resulting enantioenriched pyrrolidine products, which contain two stereogenic centers, can undergo rearrangement to yield 2,3-disubstituted piperidines with excellent diastereoselectivity and enantiospecificity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available