Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 14, Pages 5270-5273Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja4006404
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Funding
- NIH [R21EB013259, R01GM093265]
- Nanoscale Science and Engineering Center at UW-Madison [DMR-0425880]
- Fulbright Fellowship
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Host-defense peptides inhibit bacterial growth but show little toxicity toward mammalian cells. A variety of synthetic polymers have been reported to mimic this antibacterial selectivity; however, achieving comparable selectivity for fungi is more difficult because these pathogens are eukaryotes. Here we report nylon-3 polymers based on a novel subunit that display potent antifungal activity (MIC = 3.1 mu g/mL for Candida albicans) and favorable selectivity (IC10 > 400 mu g/mL for 3T3 fibroblast toxicity; HC10 > 400 mu g/mL for hemolysis).
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