4.8 Article

Palladium(0)-Catalyzed Alkynylation of C(sp3)-H Bonds

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 9, Pages 3387-3390

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja400648w

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Funding

  1. NSF under the CCI Center for Selective C-H Functionalization [CHE-1205646]
  2. Scripps Research Institute
  3. Sigma-Aldrich
  4. Bristol-Myers-Squibb
  5. Agency for Science, Technology and Research (A*STAR) Singapore
  6. Division Of Chemistry
  7. Direct For Mathematical & Physical Scien [1205646] Funding Source: National Science Foundation

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The alkynylation of beta-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L-n] complexes to activate C(sp(3))-H bonds.

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