Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 28, Pages 10314-10317Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja405120x
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Funding
- Spanish Ministerio de Economia y Competitividad [CTQ2011-23167]
- Consolider Ingenio
- Xunta de Galicia [GRC2010/12]
- INCITE09 [209084PR]
- Spanish Ministerio de Educacion
- [SAF2010-20822-C02]
- [CTQ2012-31341]
- [CSD2007-00006]
- [PGIDIT08CSA-047209PR]
- ICREA Funding Source: Custom
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A surface-enhanced Raman scattering (SERS)-based sensor was developed for the detection of the oncoprotein c-Jun at nanomolar levels. c-Jun is a member of the bZIP (basic zipper) family of dimeric transcriptional activators, and its overexpression has been associated with carcinogenic mechanisms in several human cancers. For our sensing purpose, we exploited the ability of c-Jun to heterodimerize with its native protein partner, c-Fos, and therefore designed a c-Fos peptide receptor chemically modified to incorporate a thiophenol (TP) group at the N-terminal site. The TP functionality anchors the c-Fos protein onto the metal substrate and works as an effective SERS probe to sense the structural rearrangements associated with the c-Fos/c-Jun heterodimerization.
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