Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 13, Pages 4978-4981Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja401612x
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Funding
- NIH [R21EB009853, 1R2IEB011762]
- CPRIT [RP120588]
- startup fund of the UT Dallas
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Glutathione-coated luminescent gold nanoparticles (GS-AuNPs) with diameters of similar to 2.5 nm behave like small dye molecules (IRDye 800CW) in physiological stability and renal clearance but exhibit a much longer tumor retention time and faster normal tissue clearance, indicating that the well-known enhanced permeability and retention effect, a unique strength of conventional NPs in tumor targeting, still exists in such small NPs. These merits enable the AuNPs to detect tumor more rapidly than the dye molecules without severe accumulation in reticuloendothelial system organs, making them very promising for cancer diagnosis and therapy.
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