Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 48, Pages 18145-18152Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja408516w
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Funding
- National Science Foundation [NSF-CHE-1058794]
- Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231]
- ConvEne-IGERT program at UCSB [NSF-DGE 0801627]
- PIRE-ECCI program at UCSB [NSF-OISE-0968399]
- IRES-ECCI program at UCSB [NSF-OISE-1065581]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1058794] Funding Source: National Science Foundation
- Office Of Internatl Science &Engineering
- Office Of The Director [1065581] Funding Source: National Science Foundation
- Office Of The Director
- Office Of Internatl Science &Engineering [0968399] Funding Source: National Science Foundation
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Novel materials for the phototherapeutic release of the bioregulator nitric oxide (nitrogen monoxide) are described. Also reported is a method for scanning these materials with a focused NIR beam to induce photouncaging while minimizing damage from local heating. The new materials consist of poly(dimethylsiloxane) composites with near-infrared-to-visible upconverting nanoparticles (UCNPs) that are cast into a biocompatible polymer disk (PD). These PDs are then impregnated with the photochemical nitric oxide precursor Roussin's black salt (RBS) to give UCNP_RBS_PD devices that generate NO when irradiated with 980 nm light. When the UCNP_RBS_PD composites were irradiated with NIR light through filters composed of porcine tissue, physiologically relevant NO concentrations were released, thus demonstrating the potential of such devices for minimally invasive phototherapeutic applications.
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