Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 47, Pages 17655-17658Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja404491r
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Funding
- NIH (NCI CCNE) [C54CA151880]
- NIH (CCNP) [U01CA151461]
- NIH [P30CA060553]
- NSF-NSEC
- NIH-CCNE
- NSF-MRSEC
- Keck Foundation
- State of Illinois
- NU
- NCI [T32GM008382]
- AFOSR [FA-9550-11-1-0275]
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An acid-degradable polymer-caged lipoplex (PCL) platform consisting of a cationic lipoplex core and a biocompatible, pH-responsive polymer shell has been developed for the effective delivery of small interfering RNA (siRNA) through a combination of facile loading, rapid acid-triggered release, cellular internalization, and effective endosomal escape. In vitro testing of this degradable PCL delivery platform reveals similar to 45 and similar to 2.5-fold enhancement of enhanced green fluorescent protein knockdown in cancer cells in comparison to either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.
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