4.8 Article

Cu-Catalyzed Mild C(sp2)-H Functionalization Assisted by Carboxylic Acids en Route to Hydroxylated Arenes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 25, Pages 9350-9353

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja4047894

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Funding

  1. ICIQ Foundation
  2. European Research Council [ERC-277883]
  3. MICINN [CTQ2012-34054]
  4. FPI

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A formal Cu-catalyzed C(sp(2))-H hydroxylation assisted by benzoic acids is described. The procedure is characterized by its mild reaction conditions and wide substrate scope utilizing simple and cheap Cu catalysts, thus becoming a user-friendly and operationally simple protocol for C(sp(2))-H hydroxylation.

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