4.8 Article

Pd(II)-Catalyzed Enantioselective C-H Activation/C-O Bond Formation: Synthesis of Chiral Benzofuranones

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 4, Pages 1236-1239

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja311259x

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Funding

  1. Chinese Academy of Sciences
  2. Ministry of Education [SRFDP 20123402110040]
  3. National Science Foundation of China [21102138]
  4. National Institutes of Health (NIGMS) [1 R01 GM084019-04]
  5. University of Science and Technology of China (USTC)

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Pd(II)-catalyzed enantioselective C-H activation of phenylacetic acids followed by an intramolecular C-O bond formation afforded chiral benzofuranones. This reaction provides the first example of enantioselecctive C-H functionalizations through Pd(II)/Pd(IV) redox catalysis.

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