Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 17, Pages 6392-6395Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja4001272
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Funding
- Nonequilibrium Energy Research Center
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DESC0000989]
- Energy Frontier Research Center
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Nanoparticles functionalized with mixed self-assembled monolayers (m-SAMs) comprising positively and negatively charged thiols are stable at both low and high pH but precipitate sharply at the pH where the charges on the particle are balanced (pH(prec)). By adjusting the proportion of the positively and negatively, charged ligands in the m-SAM or changing particle size, pH(prec) can be varied flexibly between similar to 4 and similar to 7. In addition, changes in the SAMs' composition and particles' net charge translate into different degrees of cellular uptake. Remarkably, the presence of the positively, charged thiols allows for the uptake of particles having net negative charge.
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