Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 14, Pages 5344-5347Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja401954t
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Funding
- MICINN [CTQ2010-21567-C02-02, BIO2012-32868]
- CSIC [I-LINK-0216]
- EU COST [MP0802]
- NSERC
- Vanier Canada Graduate Scholarship
- Sara Borrell fellowship
- CSIC-JAE
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Human telomeric DNA quadruplexes can adopt different conformations in solution. We have found that arabinose, 2'F-arabinose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conformers, allowing NMR structural determination of this particularly significant nucleic acid structure. 2'F-arabinose substitution provides the greatest stabilization as a result of electrostatic (F-CH---O4') and pseudohydrogen-bond (F---H8) stabilizing interactions. In contrast, 2'F-rG substitution provokes a dramatic destabilization of the quadruplex structure due to unfavorable electrostatic repulsion between the phosphate and the 2'-F.
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