Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 22, Pages 8133-8136Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja402910d
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Funding
- WWU Munster
- Fond der Chemischen Industrie
- DFG [HE 6020/2-1]
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Asymmetric bromolactonizations of alkynes are possible using a desymmetrization approach. The commercially available catalyst (DHQD)(2)PHAL promotes these cyclizations in combination with cheap NBS as a bromine source to give bromoenol lactones in high yield and with high enantioselectivity. The bromoenol lactone products, containing a tetrasubstituted alkene and a quaternary stereocenter are valuable building blocks for synthetic chemistry.
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