4.8 Article

Synthesis of Aryl Sulfonamides via Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 29, Pages 10638-10641

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja405949a

Keywords

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Funding

  1. National Institutes of Health [GM58160, 1F32GM099202]
  2. NSF [CHE-9808061, DBI-9729592]

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A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.

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