Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 41, Pages 15334-15337Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja408747m
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Funding
- Max-Planck-Society
- Fonds der Chemischen Industrie
- European Regional Development Fund (ERDF)
- state of North Rhine-Westphalia, Germany
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An asymmetric Mannich reaction of silyl ketene acetals with N-Boc-amino sulfones has been developed. A chiral disulfonirnide efficiently catalyzes both the in situ generation of the corresponding N-Boc imines and the asymmetric Mannich reaction with excellent yields and enantioselectivities. Kinetic studies confirm a proposed stepwise mechanism.
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