Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 51, Pages 19123-19126Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja4115055
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Funding
- National Science Foundation
- Air Force Office of Scientific Research
- Gordon and Betty Moore Foundation at Caltech
- Marie Curie International Outgoing Fellowship
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Cryo-electron microscopy is a form of transmission electron microscopy that has been used to determine the 3D structure of biological specimens in the hydrated state and with high resolution. We report the development of 4D cryo-electron microscopy by integrating the fourth dimension, time, into this powerful technique. From time-resolved diffraction of amyloid fibrils in a thin layer of vitrified water at cryogenic temperatures, we were able to detect picometer movements of protein molecules on a nanosecond time scale. Potential future applications of 4D cryo-electron microscopy are numerous, and some are discussed here.
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