Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 35, Pages 12940-12943Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja4058635
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Funding
- Ministry of Science and Technology [2009CB930000, 2011CB933201]
- Nation Science Foundation of China [21025520, 21235004]
- Chinese Academy of Science [KJCX2-YW-M15]
- China Postdoctoral Science [023260191]
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Co-presenting non-antibiotic drugs and pyrimidinethiol on gold nanoparticles (NPs) can generate broad-spectrum antibacterial and bactericidal activities against superbugs. Dimethylbiguanide (metformin), an anti-hyperglycemic drug, shows the best enhanced activity via increasing the ability to compromise bacterial cell walls. Synergistic effects are also reflected in the eradicating biofilm cells. Our findings suggest a large chemical space to develop new antibacterial materials to treat superbugs.
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