Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 40, Pages 15257-15262Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja4085463
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Funding
- National Basic Research Program of China (973 Program) [2009CB825300]
- National Science Foundation of China [21172006]
- Ph.D. Programs Foundation of the Ministry of Education of China [20120001110013]
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The Cu-catalyzed novel aerobic oxidative esterification reaction of 1,3-diones for the synthesis of alpha-ketoesters has been developed. This method combines C-C sigma-bond cleavage, dioxygen activation and oxidative C H bond functionalization, as well as provides a practical, neutral, and mild synthetic approach to alpha-ketoesters which are important units in many biologically active compounds and useful precursors in a variety of functional group transformations. A plausible radical process is proposed on the basis of mechanistic studies.
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