Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 8, Pages 2891-2894Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3114032
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Funding
- Danish National Research Foundation
- Danish Council for Strategic Research
- Carlsberg Foundation
- Villum Foundation
- Lundbeck Foundation
- Aarhus University
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A protocol for the Pd-catalyzed hydroxy-carbonylation of aryl iodides, bromides, and chlorides has been developed using only 1-5 mol % of CO, corresponding to a p(CO) as low as 0.1 bar. Potassium formate is the only stoichiometric reagent, acting as a mildly basic nucleophile and a reservoir of CO. The substoichiometric CO could be delivered to the reaction from an acyl-Pd(II) precatalyst, which provides both the CO and an active catalyst, and thereby obviates the need for handling a toxic gas.
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