Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 46, Pages 18928-18931Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja309079f
Keywords
-
Categories
Funding
- 973 Program [2013CB933800]
- National Natural Science Foundation of China [21102155, 21222210, 91027041]
- Chinese Academy of Sciences (100 Talents Program)
Ask authors/readers for more resources
We report a ratiometric fluorescent sensor based on monochlorinated BODIPY for highly selective detection of glutathione (GSH) over cysteine (Cys)/homocysteine (Hcy). The chlorine of the monochlorinated BODIPY can be rapidly replaced by thiolates of biothiols through thiol halogen nucleophilic substitution. The amino groups of Cys/Hcy but not GSH further replace the thiolate to form amino-substituted BODIPY. The significantly different photophysical properties of sulfur- and amino-substituted BODIPY enable the discrimination of GSH over Cys and Hcy. The sensor was applied for detection of GSH in living cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available