Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 24, Pages 9914-9917Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja303853y
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Funding
- National Natural Science Foundation of China [21172013, 91127034]
- National Basic Research Program of China (973 Program) [2009CB930303, 2012CB917303]
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A cell-specific metabolic glycan labeling strategy has been developed using azidosugars encapsulated in ligand-targeted liposomes. The ligands are designed to bind specific cell-surface receptors that are only expressed or up-regulated in target cells, which mediates the intracellular delivery of azidosugars. The delivered azidosugars are metabolically incorporated into cell-surface glycans, which are then imaged via a bioorthogonal reaction.
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