Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 40, Pages 16488-16491Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja306854d
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Funding
- Center for Cancer Nanotechnology Excellence (CCNE) initiative of the National Institutes of Health (NIH) [U54 CA151880]
- Nonequilibrium Energy Research Center (NERC)
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0000989]
- International Institute for Nanotechnology at Northwestern University
- Prostate Cancer Foundation
- Dixon Translational Research Grants Initiative of the Northwestern Memorial Foundation
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [R21AR062898]
- NIAMS [R01AR060810]
- Defense Advanced Research Projects Agency (DARPA)/Microsystems Technology Office (MTO) [N66001-11-1-4189]
- NSF-NSEC
- NSF-MRSEC
- Keck Foundation
- State of Illinois
- Northwestern University
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Spherical nucleic acid (SNA) constructs are promising new single entity gene regulation materials capable of both cellular transfection and gene knockdown, but thus far are promiscuous structures, exhibiting excellent genetic but little cellular selectivity. In this communication, we describe a strategy to impart targeting capabilities to these constructs through noncovalent functionalization with a complementary antibody-DNA conjugate. As a proof-of-concept, we designed HER2-targeting SNAs and demonstrated that such structures exhibit cell type selectivity in terms of their uptake, and significantly greater gene knockdown in cells overexpressing the target antigen as compared to the analogous antibody-free and off-target materials.
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