Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 32, Pages 13180-13183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3049783
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Funding
- National Science Foundation (NSF) [MPS/DMR-1008125]
- National Science Foundation (NSF) Single Investigator Award [DMR-1104773]
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Ultrasmall sub-10 nm nanoprobes and carriers are of significant interest due to their favorable biodistribution characteristics in in vivo experiments. Here we describe the one-pot synthesis of PEGylated mesoporous silica nanoparticles with a single pore, tunable sizes around 9 nm and narrow size distributions that an be labeled with near-infrared dye Cy5.5. Particles are characterized by a combination of transmission electron microscopy, dynamic light scattering, fluorescence correlation spectroscopy, optical spectroscopy, nuclear magnetic resonance spectroscopy, and nitrogen sorption/desorption measurements. The possibility to distinguish an inside and outside may render these particles an interesting subject for further studies in sensing, drug delivery, and theranostics applications.
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