Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 25, Pages 10309-10312Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3016582
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Funding
- National Research Foundation (NRF) of Korea through the Strategic Research Program [2010-0029138]
- National Research Foundation (NRF) of Korea through Global Research Laboratory Program [2011-0021628]
- National Research Foundation (NRF) of Korea through World Class University Program [R31-10013]
- Korea Healthcare Technology R&D Projects, Ministry for Health, Welfare Family Affairs [A112028]
- National Research Foundation of Korea [2011-0021628] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol-gel reaction of tantalum(V) ethoxide in a microemulsion containing Fe3O4 nanoparticles (NPs) was used to synthesize multifunctional Fe3O4/TaOx core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor.
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