Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 33, Pages 13843-13849Publisher
AMER CHEMICAL SOC
DOI: 10.1021/Ja305814u
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Funding
- National Basic Research Program (973 Program) [2012CB932600]
- National Natural Science Foundation [21075128, 20902096, 21073221, 90913014, 30928023, 30971516]
- Chinese Academy of Sciences
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In this work, we report a new concept of adaptive ensemble aptamers (ENSaptamers) that exploits the collective recognition abilities of a small set of rationally designed, nonspecific DNA sequences to identify molecular or cellular targets discriminatively. In contrast to in vitro selected aptamers, which possess specific lock-and-key recognition, ENSaptamers rely on pattern recognition that mimics natural olfactory or gustatory systems. Nanographene oxide was employed to provide a low-background and highly reproducible fluorescent assay system. We demonstrate that this platform provides a highly discriminative and adaptive tool for high precision identification of a wide range of targets for diagnostic and proteomic applications with a nearly unlimited supply of ENSaptamer receptors.
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