Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 135, Issue 1, Pages 50-53Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja310282t
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Funding
- Nagoya University Science Foundation
- Ministry of Education, Culture, Sports, Science and Technology, Japan [23750109]
- Grants-in-Aid for Scientific Research [23750109] Funding Source: KAKEN
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Water-soluble cobalt(III) porphyrin complexes were found to promote the hydration of terminal alkynes to give methyl ketones. The alkyne hydration proceeded in good to excellent yield with 0.1 to 2 mol % cobalt catalyst 1 and was compatible with the presence of acid/base- or redox-sensitive functional groups such as alkyl silyl ethers; allyl ethers; trityl ethers; benzyl ethers; carboxylic esters; boronic esters; carboxamides; nitriles; and nitro, iodo, and acetal groups. Some of the alkyne substrates tested here are otherwise difficult to hydrate. The alkyne hydration can be performed on a gram scale, and the catalyst can be recovered by aqueous workup.
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