Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 32, Pages 13148-13151Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja302447r
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Funding
- National Basic Research Program of China (973 program) [2012CB932600]
- National Natural Science Foundation of China [21028005, 90913014, 21105028, 21075128]
- ONR
- DOE
- NSF
- ARO
- Center for Bio-Inspired Solar Fuel Production
- Energy Frontier Research Center
- U.S. Department of Energy, Office of Science, Office of Basic Energy
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Three-dimensional (3D) DNA nanostructures have shown great promise for various applications including molecular sensing and therapeutics. Here we report kinetic studies of DNA-mediated charge transport (CT) within a 3D DNA nanostructure framework. A tetrahedral DNA nanostructure was used to investigate the through-duplex and through-space CT of small redox molecules (methylene blue (MB) and ferrocene (Fc)) that were bound to specific positions above the surface of the gold electrode. CT rate measurements provide unambiguous evidence that the intercalative MB probe undergoes efficient mediated CT over longer distances along the duplex, whereas the nonintercalative Fc probe tunnels electrons through the space. This study sheds new light on DNA-based molecular electronics and on designing high-performance biosensor devices.
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